Squid liver may help fight kidney disease

Scientists have found that the liver of the Far Eastern squid, or rather synaptamide derived from it, can very effectively suppress inflammation in renal tissue after ischemia of the organ. This work was published in the popular resource International Journal of Molecular Sciences.

As it is noted, for the first time biologists were able to prove that synaptamide really reduces the active formation of pro-inflammatory molecules in renal tissues and reduces the flow of leukocytes into them. These studies will help experts both in the treatment of kidney failure and in understanding the mechanism by which synaptamide works.

In fact, synaptamide is a derivative of unsaturated fatty acids, the presence of which has been noted in the livers of a number of marine species, including Far Eastern squid and salmon, and recently experts have found that synaptamide can cope with inflammation in nerve damage and even brain damage.

In their research, scientists artificially induced ischemia of one kidney in 30 experimental rats and observed how synaptamide injected into the rodents changed the state of this organ, noting changes in the volume of signaling molecules that promote inflammation and control the activity of immune cells.

In the end, it was found that synaptamide, when interacting with the GPR110 receptor, helped prevent a dramatic increase in the levels of IL-1b and IL-6 proteins, as well as other signaling molecules that promote inflammation in the liver after ischemia.

The biologists are confident that the combination of synaptamide with certain drugs designed to protect kidney cells from damage will lead to an advanced therapy for renal ischemia in the near future. In addition, after further studies, it will be possible to say that synaptamide will also help fight inflammation in other organs.

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